Cervical cancer prevention
The recently introduced HPV-vaccination for twelve year old girls will likely impact the cost-effectiveness of cervical screening in later years. We model cervical cancer to estimate the impact of HPV vaccination on cervical cancer screening to inform authorities in advance on potential new ways to optimise cervical cancer prevention. Read more
Colorectal cancer prevention
Recently, colorectal cancer screening has been introduced in the Netherlands. This screening programme is expected to impact cancer incidence and mortality rates. We have developed the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model to evaluate this long-term impact of the Dutch screening programme. Read more
The PATTERN model
The Personalized Adjuvant TreaTment in EaRly stage coloN cancer (PATTERN) model is a Markov cohort model developed to evaluate strategies for the allocation of adjuvant chemotherapy in stage II colon cancer patients. Read more
Optimizing lung cancer care
In the last years new treatments and treatment strategies for non-small cell lung cancer (NSCLC) have been developed. We developed and validated a decision model to evaluate long-term health effects, costs, and cost-effectiveness. Read more
Biomarker-based Bayesian-adaptive trial design
The goal of this project is to make all the necessary preparations for running and analyzing a clinical trial to decide on the optimal targeted treatment strategy for patients with diffuse large B-cell lymphoma (DLBCL). Read more
The MAICare cancer modeling framework
The Microsimulation model for the Assessment of Individualized Cancer Care (MAICare) is a microsimulation model framework that describes the cancer disease process. It uses a description of underlying tumor growth as well as its interaction with diagnostics, treatments and surveillance. The framework allows for exploration of the impact of simultaneously altering two or more aspects of the care process. Read more
Response evaluation in oropharyngeal cancer
The effectiveness chemoradiation in patients with advanced oropharyngeal cancer is evaluated with an invasive procedure. Can the number of (unnecessary) invasive tests be reduced. Read more